DECREASED TRABECULAR SMOOTH MUSCLE AND CAVEOLIN-1 EXPRESSION IN THE PENILE TISSUE OF AGED RATS
作者： MUSTAFA E BAKIRCIOGLU , KARL-DIETRICH SIEVERT , LORA NUNES , ANGIE LAU , CHING-SHWUN LIN
DOI: 10.1016/S0022-5347(05)66052-1
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摘要: Purpose: Because decreased trabecular smooth muscle content is reportedly associated with vasculogenic impotence in men, we performed a rodent study to investigate the effect of aging on and caveolin-1 protein expression penile cells.Materials Methods: In 6 young (age 3 months) old 24 rats erectile function was evaluated by cavernous nerve stimulation. At sacrifice tissue samples were collected for Western blot analysis, Masson’s trichrome staining, immunostaining electron microscopy. The percent assessed computer assisted image analysis.Results: aged mean intracavernous pressure plus or minus standard deviation (70 ± 8.8 versus 107 12.3 cm. water) latency period increased (7.8 1.2 4.5 0.5 seconds) significantly compared values (p <0.001). ratio muscle-to-connecti...
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