Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19.
作者： Akiko Toda , Shotaro Uehara , Takashi Inoue , Masahiro Utoh , Takashi Kusama
DOI: 10.1080/00498254.2017.1353716
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摘要: Abstract1. The pharmacokinetics were investigated for human cytochrome P450 probes after single intravenous and oral administrations of 0.20 1.0 mg/kg, respectively, caffeine, warfarin, omeprazole, metoprolol midazolam to aged (10–14 years old, n = 4) or rifampicin-treated/young (3 years n = 3) male common marmosets all genotyped as heterozygous a 2C19 variant.2. Slopes the plasma concentration–time curves administration warfarin slightly, but significantly (two-way analysis variance), decreased in compared with young marmosets. mean hepatic clearances determined by silico fitting individual pharmacokinetic models group were, 23% 56% smaller than those group.3. Significantly enhanced omeprazole evident pretreated rifampicin (25 mg/kg daily 4 da...
sci-hub.se 参考文章(31)
Donald J. Birkett, Tommy Andersson, John O. Miners, Assays of omeprazole metabolism as a substrate probe for human CYP isoforms Methods in Enzymology. ,vol. 272, pp. 132- 139 ,(1996) , 10.1016/S0076-6879(96)72016-5
Satomi Shida, Masahiro Utoh, Norie Murayama, Makiko Shimizu, Yasuhiro Uno, Hiroshi Yamazaki, Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling. Xenobiotica. ,vol. 45, pp. 881- 886 ,(2015) , 10.3109/00498254.2015.1028511
Use of Prescription and Over-the-counter Medications and Dietary Supplements Among Older Adults in the United States JAMA. ,vol. 300, pp. 2867- 2878 ,(2008) , 10.1001/JAMA.2008.892
Shotaro Uehara, Takashi Inoue, Masahiro Utoh, Akiko Toda, Makiko Shimizu, Yasuhiro Uno, Erika Sasaki, Hiroshi Yamazaki, Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus) Xenobiotica. ,vol. 46, pp. 163- 168 ,(2016) , 10.3109/00498254.2015.1057270
Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Takako Suzuki, Masahiro Utoh, Erika Sasaki, Hiroshi Yamazaki, Caffeine 7-N-demethylation and C-8-oxidation mediated by liver microsomal cytochrome P450 enzymes in common marmosets. Xenobiotica. ,vol. 46, pp. 573- 578 ,(2016) , 10.3109/00498254.2015.1096980
P Maurel, I Fabre, G Fabre, J Combalbert, I Dalet, J P Cano, J Derancourt, Metabolism of cyclosporin A. IV: Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily Drug Metabolism and Disposition. ,vol. 17, pp. 197- 207 ,(1989)
Berit Packert Jensen, Paul Ken Leong Chin, Rebecca Lee Roberts, Evan James Begg, None, Influence of adult age on the total and free clearance and protein binding of (R)- and (S)-warfarin. British Journal of Clinical Pharmacology. ,vol. 74, pp. 797- 805 ,(2012) , 10.1111/J.1365-2125.2012.04259.X
Yukio Ishizawa, Norio Yasui-Furukori, Takenori Takahata, Mutsuo Sasaki, Tomonori Tateishi, The Effect of Aging on the Relationship between the Cytochrome P450 2C19 Genotype and Omeprazole Pharmacokinetics Clinical Pharmacokinectics. ,vol. 44, pp. 1179- 1189 ,(2005) , 10.2165/00003088-200544110-00005
Sandrine Turpault, William Brian, Robert Van Horn, Alix Santoni, Franck Poitiers, Yves Donazzolo, Xavier Boulenc, Pharmacokinetic assessment of a five-probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A British Journal of Clinical Pharmacology. ,vol. 68, pp. 928- 935 ,(2009) , 10.1111/J.1365-2125.2009.03548.X
A PARKINSON, The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes. Toxicology and Applied Pharmacology. ,vol. 199, pp. 193- 209 ,(2004) , 10.1016/J.TAAP.2004.01.010