Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender.

摘要: Oxidative stress (OS) plays a key role in the muscle impairment and exercise capacity of COPD patients. However, literature reveals that systemic OS markers show great heterogeneity, which may hinder prescription effective antioxidant supplementation. This study therefore aimed to identify imbalance patients, relative validated normal reference values, investigate possibility profiles. We measured enzymatic/nonenzymatic lipid peroxidation (LP) levels 54 stable patients referred for rehabilitation program. The main deficits these concerned vitamins trace elements. Fully 89% showed have caused elevated LP 69% them. Interestingly, two patient profiles (clusters 3 4) had more increase combined with increased copper and/or decreased vitamin C, GSH, GPx. Further analysis revealed level was higher women associated capacity. Our present data support future supplementations elements improve capacity, but will probably different positive responses.