Selenium Attenuates Lipopolysaccharide-Induced Oxidative Stress Responses Through Modulation of p38 MAPK and NF-κB Signaling Pathways:
作者： Sang Hyun Kim , Victor J. Johnson , Tae-Yong Shin , Raghubir P. Sharma
DOI: 10.1177/153537020422900209
关键词:
摘要: Lipopolysaccharide (LPS) produces reactive oxygen species (ROS) and nitric oxide (NO) in macrophages. These molecules are involved inflammation associated with endotoxic shock. Selenium (Se), a biologically essential trace element, modulates the functions of many regulatory proteins signal transduction affects variety cellular activities, including cell growth survival. We demonstrate that Se attenuated LPS-induced ROS NO production murine macrophage cultures vitro. This Se-decreased was demonstrated by decreases both mRNA protein expression for inducible synthase (INOS). The preventive effects on INOS were p38 mitogen-activated kinase- nuclear factor-κB-dependent. specifically blocked activation but not c-jun-N-terminal kinase extracellular signal-regulated kinase; p38-specific pathway confirmed using inhibitor SB 203580. results suggest mechanism which Se...
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sci-hub.se 参考文章(44)
Timothy S. Finco, Albert S. Baldwin, Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis Immunity. ,vol. 3, pp. 263- 272 ,(1995) , 10.1016/1074-7613(95)90112-4
Raghubir P. Sharma, Neetesh Bhandari, Masashi Tsunoda, R.T. Riley, K.A. Voss, Fumonisin hepatotoxicity is reduced in mice carrying the human tumour necrosis factor α transgene Archives of Toxicology. ,vol. 74, pp. 238- 248 ,(2000) , 10.1007/S002040000106
Frank Tietze, Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues Analytical Biochemistry. ,vol. 27, pp. 502- 522 ,(1969) , 10.1016/0003-2697(69)90064-5
Sang Hyun Kim, Victor J Johnson, Raghubir P Sharma, Mercury inhibits nitric oxide production but activates proinflammatory cytokine expression in murine macrophage: differential modulation of NF-κB and p38 MAPK signaling pathways Nitric Oxide. ,vol. 7, pp. 67- 74 ,(2002) , 10.1016/S1089-8603(02)00008-3
Rony Seger, Edwin G. Krebs, The MAPK signaling cascade. The FASEB Journal. ,vol. 9, pp. 726- 735 ,(1995) , 10.1096/FASEBJ.9.9.7601337
J.A. Royall, H. Ischiropoulos, Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells. Archives of Biochemistry and Biophysics. ,vol. 302, pp. 348- 355 ,(1993) , 10.1006/ABBI.1993.1222
Varda Ben-Shaul, Liat Lomnitski, Abraham Nyska, Yehuda Zurovsky, Margalit Bergman, Shlomo Grossman, The effect of natural antioxidants, NAO and apocynin, on oxidative stress in the rat heart following LPS challenge Toxicology Letters. ,vol. 123, pp. 1- 10 ,(2001) , 10.1016/S0378-4274(01)00369-1
William C Sha, Hsiou-Chi Liou, Elaine I Tuomanen, David Baltimore, Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses Cell. ,vol. 80, pp. 321- 330 ,(1995) , 10.1016/0092-8674(95)90415-8
Hideaki Kamata, Hajime Hirata, Redox Regulation of Cellular Signalling Cellular Signalling. ,vol. 11, pp. 1- 14 ,(1999) , 10.1016/S0898-6568(98)00037-0
Hee-Sae Park, Eun Park, Mi-Sung Kim, Kwangseog Ahn, Ick Young Kim, Eui-Ju Choi, Selenite inhibits the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through a thiol redox mechanism. Journal of Biological Chemistry. ,vol. 275, pp. 2527- 2531 ,(2000) , 10.1074/JBC.275.4.2527