Central non-opioid physiological and pathophysiological effects of dynorphin A and related peptides.
作者： S Lemaire , V K Shukla
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摘要: Dynorphin A (Dyn A) and related opioid peptides derived from prodynorphin possess a high affinity for kappa receptors, but they also bind to other receptors (mu delta) as well some non-opioid receptor sites. Although the physiological role of these is not established, recent experimental data pinpoint their particular involvement in pathophysiological conditions that relate algesia, spinal cord injury epilepsy. In this paper, we review which support concept behavioral effects Dyn endogenous are observed under physiologically pathophysiologically relevant.
参考文章(14)
T Kanamatsu, JF McGinty, CL Mitchell, JS Hong, Dynorphin- and enkephalin-like immunoreactivity is altered in limbic- basal ganglia regions of rat brain after repeated electroconvulsive shock The Journal of Neuroscience. ,vol. 6, pp. 644- 649 ,(1986) , 10.1523/JNEUROSCI.06-03-00644.1986
T Kanamatsu, J Obie, L Grimes, JF McGinty, K Yoshikawa, S Sabol, JS Hong, Kainic acid alters the metabolism of Met5-enkephalin and the level of dynorphin A in the rat hippocampus The Journal of Neuroscience. ,vol. 6, pp. 3094- 3102 ,(1986) , 10.1523/JNEUROSCI.06-10-03094.1986
M.F. Piercey, K. Varner, L.A. Schroeder, Analgesic activity of intraspinally administered dynorphin and ethylketocyclazocine. European Journal of Pharmacology. ,vol. 80, pp. 283- 284 ,(1982) , 10.1016/0014-2999(82)90072-3
M. A. Ruda, M. J. Iadarola, L. V. Cohen, W. S. Young, In situ hybridization histochemistry and immunocytochemistry reveal an increase in spinal dynorphin biosynthesis in a rat model of peripheral inflammation and hyperalgesia Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 622- 626 ,(1988) , 10.1073/PNAS.85.2.622
Frank C. Tortella, Endogenous opioid peptides and epilepsy: quieting the seizing brain? Trends in Pharmacological Sciences. ,vol. 9, pp. 366- 372 ,(1988) , 10.1016/0165-6147(88)90256-8
David S. Roane, Johnny R. Porter, Nociception and opioid-induced analgesia in lean (Fa/-) and obese (fa/fa) Zucker rats. Physiology & Behavior. ,vol. 38, pp. 215- 218 ,(1986) , 10.1016/0031-9384(86)90156-3
Alan I. Faden, Opioid and nonopioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury. Annals of Neurology. ,vol. 27, pp. 67- 74 ,(1990) , 10.1002/ANA.410270111
David S. Roane, Michael J. Iadarola, Johnny R. Porter, Decreased [3H]-naloxone binding and elevated dynorphin-A(1–8) content in Zucker rat brain Physiology & Behavior. ,vol. 43, pp. 371- 374 ,(1988) , 10.1016/0031-9384(88)90201-6
Henry Khachaturian, Stanley J. Watson, Michael E. Lewis, David Coy, Avram Goldstein, Huda Akil, Dynorphin Immunocytochemistry in the Rat Central Nervous System Peptides. ,vol. 3, pp. 941- 954 ,(1982) , 10.1016/0196-9781(82)90063-8
Mark W. Friederich, Douglas P. Friederich, J. Michael Walker, Effects of Dynorphin (1–8) on movement: Non-opiate effects and structure-activity relationship Peptides. ,vol. 8, pp. 837- 840 ,(1987) , 10.1016/0196-9781(87)90068-4