The predictive potential and oncogenic effects of HOXC8 expression on osteosarcoma
作者： Li Cheng , Xiaojie Wei , Keqi Zhao , Fenzan Wu , Wenjie Lu
DOI: 10.1007/S13277-016-5384-4
关键词:
摘要: Homeobox C8 (HOXC8) has been implicated in cell growth, migration, and metastasis of various cancers, yet its role osteosarcoma remains to be explored. In the present study, resected specimens from 50 patients were enrolled evaluate expression HOXC8 protein by immunohistochemistry (IHC). vitro vivo assays used determine effect on tumor growth. was observed 31 (62.0 %) primary tumors significantly associated with poorly or un-differentiated (P = 0.031) larger size 0.049). Survival analysis demonstrated that is a candidate predictive factor predicting patients’ outcome chemotherapeutic effect. knockdown led inhibition proliferation migration inhibiting MMP-9 growth vivo. Our results strongly suggest involved tumorigenesis might serve as novel predictor for outcome.
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