Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer's disease by inhibition of glial activation, cholinesterase, and oxidative stress.
作者： Hamid Sohanaki , Tourandokht Baluchnejadmojarad , Farnaz Nikbakht , Mehrdad Roghani
DOI: 10.1016/J.BIOPHA.2016.06.021
关键词:
摘要: Abstract Alzheimer’s disease (AD) is a multifactorial disorder with devastating outcomes and few mostly palliative available therapeutic strategies. Pelargonidin (Pel), an anthocyanin compound, estrogen receptor agonist lower side effects versus estrogen. This study examined neuroprotective effect of Pel on intrahippocampal amyloid β25-35 (Aβ) rat model AD. Rats were divided into groups sham, Aβ, Pel-pretreated Aβ (10 mg/kg; p.o.). Animals underwent Morris water maze (MWM) test in addition to measurement hippocampal oxidative stress, acetylcholinesterase (AChE) activity, glial fibrillary acidic protein (GFAP) inducible nitric oxide synthase (iNOS). pretreatment group significantly improved escape latency distance swum MWM attenuated malondialdehyde (MDA) increased catalase activity no significant change nitrite. Meanwhile, AChE lowered GFAP level iNOS. Our results suggest that could improve Aβ25-35-induced memory deficit through mitigation cholinergic dysfunction, astrocyte reaction.
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