Study on effectiveness of transfusion program in thalassemia major patients receiving multiple blood transfusions at a transfusion centre in Western India.

摘要: Background : Children suffering from beta-thalassemia major require repeated blood transfusions which may be associated with dangers like iron overload and contraction of infections such as HIV, HCV, HBsAg ultimately curtail their life span. On the other hand, inadequate lead to severe anemia general fatigue debility. Materials Methods: Data were obtained 142 patients aged 3 years or more receiving regular at a transfusion centre in Western India 1 April 2009 30 June 2009. The clinical data laboratory results subsequently analyzed. Results: Of patients, 76 (53.5%) undertransfused (mean Hb Conclusions: study suggests need step up achieve hemoglobin goal 10 gm% (as per moderate regimen) also institute urgent effective chelation measures aim keeping serum ferritin levels below 1000 ng/ml avoid systemic effects overload. In addition, strict monitoring children for endocrinopathy should done. Rigid implementation quality control ELISA kits used detect HCV donor needs done urgently. Alternately, sensitive specific (like NAT testing) employed detection HCV. absence definitive cure accessible available all above suggested will go long way improving (and quantity) major.