Biomedical Involvements of Low-Abundance Proteins

摘要: This chapter deals essentially with the variegated world of human proteomics, perhaps most important all fields proteomic analysis, due to its implications for health and care. Most focus is on biomarker discovery, a field that has suffered serious setbacks in last decade been heavily criticized editorials highly visible journals. After reviewing basic concepts pertaining various sections survey detail low-abundance data biological fluids, such as bile, saliva, cerebrospinal fluid, urine, serum/plasma, well variety other interesting tears, amniotic, synovial, nipple aspirate, bronchoalveolar, follicular fluids. The major findings fluids are reported, some limitations research topics. Some examples tissues cells illustrated, extensive mapping cytoplasm red blood one example tissue proteomics. ends relatively novel application peptide library discovery allergens. Although present trace amounts, they could be extremely strong activating immunological system. Conclusions drawn real possibility CPLLs will lead discoveries arena innumerable applications health.