Torso: Torso PTK (D. melanogaster)

摘要: Torso is a PTK with probable receptor function that required for determination of anterior and posterior terminal structures in the Drosophila melanogaster embryo. The torso phenotype maternal-effect lethal; embryos from homozygous mothers show alterations anterior-posterior pattern. Loss-of-function mutant lack anterior-most head to seventh abdominal segment (abdominal eight telson). Gain embryos, on other hand, defects middle have enlarged structures. mutations express protein deletions or point kinase domain. Gain-of-function causing ligand-independent activation are located extra cytoplasmic likely be activated by ligand present perivitelline space early embryo, binds extracytoplasmic part protein. Candidates molecule those genes act upstream genetic tests: trunk, torso-like, fs(1)polehole, fs(1) Nasrat.