The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

Ritchie E. Brown, Olga A. Sergeeva, Krister S. Eriksson, Helmut L. Haas, Convergent Excitation of Dorsal Raphe Serotonin Neurons by Multiple Arousal Systems (Orexin/Hypocretin, Histamine and Noradrenaline) The Journal of Neuroscience. ,vol. 22, pp. 8850- 8859 ,(2002) , 10.1523/JNEUROSCI.22-20-08850.2002

Kaoru Takakusaki, Kazumi Takahashi, Kazuya Saitoh, Hirofumi Harada, Toshikatsu Okumura, Yukihiko Kayama, Yoshimasa Koyama, Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy The Journal of Physiology. ,vol. 568, pp. 1003- 1020 ,(2005) , 10.1113/JPHYSIOL.2005.085829

Joseph LeDoux, The emotional brain, fear, and the amygdala. Cellular and Molecular Neurobiology. ,vol. 23, pp. 727- 738 ,(2003) , 10.1023/A:1025048802629

Christelle Peyron, Juliette Faraco, William Rogers, Beth Ripley, Sebastiaan Overeem, Yves Charnay, Sona Nevsimalova, Michael Aldrich, David Reynolds, Roger Albin, Robin Li, Marcel Hungs, Mario Pedrazzoli, Muralidhara Padigaru, Melanie Kucherlapati, Jun Fan, Richard Maki, Gert Jan Lammers, Constantin Bouras, Raju Kucherlapati, Seiji Nishino, Emmanuel Mignot, None, A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains Nature Medicine. ,vol. 6, pp. 991- 997 ,(2000) , 10.1038/79690

John H. Martin, Neuroanatomy: Text and Atlas ,(1989)

Thierry Gallopin, Patrice Fort, Emmanuel Eggermann, Bruno Cauli, Pierre-Hervé Luppi, Jean Rossier, Etienne Audinat, Michel Mühlethaler, Mauro Serafin, Identification of sleep-promoting neurons in vitro Nature. ,vol. 404, pp. 992- 995 ,(2000) , 10.1038/35010109

Christelle Peyron, Devin K. Tighe, Anthony N. van den Pol, Luis de Lecea, H. Craig Heller, J. Gregor Sutcliffe, Thomas S. Kilduff, Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems The Journal of Neuroscience. ,vol. 18, pp. 9996- 10015 ,(1998) , 10.1523/JNEUROSCI.18-23-09996.1998

Gareth Williams, Chen Bing, Xue J Cai, Joanne A Harrold, Peter J King, Xiao H Liu, The hypothalamus and the control of energy homeostasis: Different circuits, different purposes Physiology & Behavior. ,vol. 74, pp. 683- 701 ,(2001) , 10.1016/S0031-9384(01)00612-6

Brian A. Baldo, Lisa Gual-Bonilla, Karuna Sijapati, Roger A. Daniel, Charles F. Landry, Ann E. Kelley, Activation of a subpopulation of orexin/hypocretin-containing hypothalamic neurons by GABAA receptor-mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment. European Journal of Neuroscience. ,vol. 19, pp. 376- 386 ,(2004) , 10.1111/J.1460-9568.2004.03093.X

M. Mieda, J. T. Willie, J. Hara, C. M. Sinton, T. Sakurai, M. Yanagisawa, Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 4649- 4654 ,(2004) , 10.1073/PNAS.0400590101