Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis.
作者： Alessandro Rimessi , Valentino Bezzerri , Simone Patergnani , Saverio Marchi , Giulio Cabrini
DOI: 10.1038/NCOMMS7201
关键词:
摘要: The common pathological manifestation of cystic fibrosis (CF) is associated with an excessive lung inflammatory response characterized by interleukin-1β accumulation. CF airway epithelial cells show exacerbated pro-inflammatory to Pseudomonas aeruginosa; however, it unclear whether this heightened intrinsic lacking transmembrane conductance regulator (CFTR). Here we demonstrate that the degree and quality in are supported P. aeruginosa-dependent mitochondrial perturbation, which flagellin inducer Ca(2+) uniporter (MCU) a signal-integrating organelle member for NLRP3 activation IL-1β IL-18 processing. Our work elucidates regulation inflammasome deepens our understanding significance mitochondria Ca(2+)-dependent control inflammation.
nature.com
core.ac.uk
harvard.edu
sci-hub.se 参考文章(49)
Haitao Wen, Jenny P-Y Ting, Luke A J O'Neill, A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation? Nature Immunology. ,vol. 13, pp. 352- 357 ,(2012) , 10.1038/NI.2228
Fayyaz S. Sutterwala, Stefanie Haasken, Suzanne L. Cassel, Mechanism of NLRP3 inflammasome activation Annals of the New York Academy of Sciences. ,vol. 1319, pp. 82- 95 ,(2014) , 10.1111/NYAS.12458
Sanjeev Mariathasan, Kim Newton, Denise M. Monack, Domagoj Vucic, Dorothy M. French, Wyne P. Lee, Meron Roose-Girma, Sharon Erickson, Vishva M. Dixit, Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf Nature. ,vol. 430, pp. 213- 218 ,(2004) , 10.1038/NATURE02664
Hara Levy, Amy Murphy, Fei Zou, Craig Gerard, Barbara Klanderman, Brooke Schuemann, Ross Lazarus, K. Christopher García, Juan C. Celedón, Mitch Drumm, Mary Dahmer, Michael Quasney, Kaitlyn Schneck, Melissa Reske, Michael R. Knowles, Gerald B. Pier, Christoph Lange, Scott T. Weiss, IL1B polymorphisms modulate cystic fibrosis lung disease. Pediatric Pulmonology. ,vol. 44, pp. 580- 593 ,(2009) , 10.1002/PPUL.21026
Rongbin Zhou, Amir S. Yazdi, Philippe Menu, Jürg Tschopp, A role for mitochondria in NLRP3 inflammasome activation Nature. ,vol. 469, pp. 221- 225 ,(2011) , 10.1038/NATURE09663
Michela Renier, Anna Tamanini, Elena Nicolis, Rossella Rolfini, Jean-Luc Imler, Andrea Pavirani, Giulio Cabrini, Use of a Membrane Potential-Sensitive Probe to Assess Biological Expression of the Cystic Fibrosis Transmembrane Conductance Regulator Human Gene Therapy. ,vol. 6, pp. 1275- 1283 ,(1995) , 10.1089/HUM.1995.6.10-1275
Geun-Shik Lee, Naeha Subramanian, Andrew I. Kim, Ivona Aksentijevich, Raphaela Goldbach-Mansky, David B. Sacks, Ronald N. Germain, Daniel L. Kastner, Jae Jin Chae, The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP Nature. ,vol. 492, pp. 123- 127 ,(2012) , 10.1038/NATURE11588
Berta Cillero-Pastor, Beatriz Caramés, Marcos Lires-Deán, Carlos Vaamonde-García, Francisco J. Blanco, María J. López-Armada, Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes. Arthritis & Rheumatism. ,vol. 58, pp. 2409- 2419 ,(2008) , 10.1002/ART.23644
Zhenyu Zhong, Yougang Zhai, Shuang Liang, Yasuo Mori, Renzhi Han, Fayyaz S. Sutterwala, Liang Qiao, TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nature Communications. ,vol. 4, pp. 1611- 1611 ,(2013) , 10.1038/NCOMMS2608
Naeha Subramanian, Kannan Natarajan, Menna R. Clatworthy, Ze Wang, Ronald N. Germain, The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell. ,vol. 153, pp. 348- 361 ,(2013) , 10.1016/J.CELL.2013.02.054