Neurturin's Role in Sensory Neuron Plasticity

作者: Ting Wang

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摘要: Primary sensory neurons are one of the major components peripheral nervous system and required for collecting transmitting information regarding external internal environment to central (CNS). The cell bodies these located in ganglia adjacent spinal cord associated with cranial nerves V, VII, IX X (cranial I, II, VIII also carry but have specialized organs that detect specific stimuli). whose cells found (also called dorsal root (DRG)) been focus intense scientific investigation because their role sensation including those pain as a model understanding mechanisms development plasticity. studies presented this dissertation on interactions between primary growth factors regulate developmental events, well adult physiology. In particular, examine respond factor neurturin (NRTN), majority which innervate epidermis.

参考文章(159)
Melissa Zwick, Brian M. Davis, C. Jeffrey Woodbury, John N. Burkett, H. Richard Koerber, James F. Simpson, Kathryn M. Albers, Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse. The Journal of Neuroscience. ,vol. 22, pp. 4057- 4065 ,(2002) , 10.1523/JNEUROSCI.22-10-04057.2002
Y.A. Barde, D. Edgar, H. Thoenen, Purification of a new neurotrophic factor from mammalian brain. The EMBO Journal. ,vol. 1, pp. 549- 553 ,(1982) , 10.1002/J.1460-2075.1982.TB01207.X
Nicolas Voilley, Jan de Weille, Julien Mamet, Michel Lazdunski, Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors The Journal of Neuroscience. ,vol. 21, pp. 8026- 8033 ,(2001) , 10.1523/JNEUROSCI.21-20-08026.2001
H KOERBER, C WOODBURY, Comprehensive phenotyping of sensory neurons using an ex vivo somatosensory system Physiology & Behavior. ,vol. 77, pp. 589- 594 ,(2002) , 10.1016/S0031-9384(02)00904-6
Margaret P. Price, Gary R. Lewin, Sabrina L. McIlwrath, Chun Cheng, Jinghui Xie, Paul A. Heppenstall, Cheryl L. Stucky, Anne G. Mannsfeldt, Timothy J. Brennan, Heather A. Drummond, Jing Qiao, Christopher J. Benson, Deirdre E. Tarr, Ron F. Hrstka, Baoli Yang, Roger A. Williamson, Michael J. Welsh, The mammalian sodium channel BNC1 is required for normal touch sensation. Nature. ,vol. 407, pp. 1007- 1011 ,(2000) , 10.1038/35039512
Robert D. Klein, Daniel Sherman, Wei-Hsien Ho, Donna Stone, Gregory L. Bennett, Barbara Moffat, Richard Vandlen, Laura Simmons, Qimin Gu, Jo-Anne Hongo, Brigitte Devaux, Kris Poulsen, Mark Armanini, Chika Nozaki, Naoya Asai, Audrey Goddard, Heidi Phillips, Chris E. Henderson, Masahide Takahashi, Arnon Rosenthal, A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor Nature. ,vol. 387, pp. 717- 721 ,(1997) , 10.1038/42722
VM Verge, JP Merlio, J Grondin, P Ernfors, H Persson, RJ Riopelle, T Hokfelt, PM Richardson, Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: responses to injury and infusion of NGF. The Journal of Neuroscience. ,vol. 12, pp. 4011- 4022 ,(1992) , 10.1523/JNEUROSCI.12-10-04011.1992
Cheryl L. Stucky, Gary R. Lewin, Isolectin B4-Positive and -Negative Nociceptors Are Functionally Distinct The Journal of Neuroscience. ,vol. 19, pp. 6497- 6505 ,(1999) , 10.1523/JNEUROSCI.19-15-06497.1999