Δ6 fatty acid desaturases in polyunsaturated fatty acid biosynthesis: insights into the evolution, function with substrate specificities and biotechnological use.
作者： Jie Cui , Haiqin Chen , Xin Tang , Jianxin Zhao , Hao Zhang
DOI: 10.1007/S00253-020-10958-5
关键词:
摘要: Δ6 fatty acid desaturases (FADS6) have different substrate specificities that impact the ratio of omega-6/omega-3 polyunsaturated acids, which are involved in regulating multiple signalling pathways associated with various diseases. For decades, FADS6 been characterized and functions these crucial enzymes investigated, while it remains enigmatic from species a huge difference. This review summarizes reveals underlying relationship. Further evaluation biochemical properties has revealed prefer linoleic is more hydrophilic stable. Domain-swapping site-directed mutagenesis employed to delineate regions sites affect FADS6. These analyses improve our understanding offer information for discovery novel biological resources. KEY POINTS: • Outline excavation identification desaturases. Overview methods used determine pivotal resides Application generate specific acids.
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