Synaptosome-Associated Protein 25 ( SNAP25 ) Gene Association Analysis Revealed Risk Variants for ASD, in Iranian Population
作者： Mohammad reza Safari , Mir Davood Omrani , Rezvan Noroozi , Arezou Sayad , Shaghayegh Sarrafzadeh
DOI: 10.1007/S12031-016-0860-2
关键词:
摘要: Autism spectrum disorder (ASD) is a common, complex neurological condition, affecting approximately 1% of people worldwide. Monogenic neurodevelopmental disorders which showed autistic behavior patterns have suggested synaptic dysfunction, as key mechanism in the pathophysiology ASD. Subsequently, genes involved signaling been investigated with priority for candidate gene studies. A synaptosomal-associated protein 25 (SNAP25) plays crucial role central nervous system, contributing to exocytosis by targeting and fusion vesicles cell membrane. Studies shown correlation between aberrant expression SNAP25 variety brain diseases. Single nucleotide polymorphisms (SNPs) this are associated several psychiatric diseases, such bipolar, schizophrenia, attention-deficit/hyperactivity disorder. The aim present study was investigate whether (rs3746544 rs1051312) regulatory 3′-untranslated region (3′UTR) an association ASD unrelated Iranian case (N = 524)-control (N = 472) samples. We observed robust rs3746544 SNP patients, both allele haplotype-based analyses. Our results supported previous observations indicated possible susceptibility genetic factors developing
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