Effect of lipophilicity of amylamine and amylglycine ligands on biological activity of new anticancer cisplatin analog.
作者： Fatemeh Safa Shams Abyaneh , Mahboube Eslami Moghadam , Moayad Hossaini Sadr , Adeleh Divsalar
DOI: 10.1080/07391102.2017.1301273
关键词:
摘要: Investigation of side effects and solubility anticancer drugs is a major challenge in chemotherapy science. Thus, design synthesis cisplatin analogs with higher lipophilicity as novel water-soluble valuable. In this work, two new Pt(II) complexes were synthesized formula cis-[Pt(NH3)2(amylgly)]NO3 cis-[Pt(amylamine)2(amylgly)]NO3, where gly penthyl glycine an amino acid. The compounds extensively characterized using analytical techniques; spectroscopic methods, conductivity measurement. activity was investigated against colon cancer cell line HCT116 MTT assay results showed excellent Cc50 values 36 270 M after 24-h incubation time for cis-[Pt(NH2-amyl)2(amylgly)]NO3, respectively; which lower than that cisplatin. These also interacted highly polymerized calf thymus DNA the binding mode th...
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