Flow studies in a model carotid bifurcation.

作者: F W LoGerfo , M D Nowak , W C Quist , H M Crawshaw , B K Bharadvaj

DOI: 10.1161/01.ATV.1.4.235

关键词:

摘要: Boundary layer separation in a plexiglass model carotid bifurcation was investigated relation to the origin of atherosclerotic plaque clinically found this region. Our comparable human both dimensions and geometry. Water flowed through at Reynolds numbers from 200 1200 under steady pulsatile flow conditions, with outflow external internal branches varied. The near-wall visualized by slow injection dye ports machined model. Under physiological number 500 split similar that rest, boundary occur sinus across origin, forming shell slowly moving fluid around bifurcation. rapidly mainstream impinged directly on divider. location correlates best low shear region not high Preliminary studies demonstrated little change results.

参考文章(14)
K. Balasubramanian, D. P. Giddens, R. F. Mabon, Steady Flow at the Carotid Bifurcation Springer, Boston, MA. pp. 475- 496 ,(1980) , 10.1007/978-1-4757-4610-5_25
Stewart Wolf, Nicholas T. Werthessen, Hemodynamic Contribution to Atherosclerosis Springer, Boston, MA. pp. 353- 466 ,(1979) , 10.1007/978-1-4684-7508-1_7
E. Marc Parmentier, William A. Morton, Harry E. Petschek, Platelet aggregate formation in a region of separated blood flow Physics of Fluids. ,vol. 20, pp. 2012- 2021 ,(1977) , 10.1063/1.861833
W.H. Gutstein, D.J. Schneck, J.O. Marks, In vitro studies of local blood flow disturbance in a region of separation Journal of Atherosclerosis Research. ,vol. 8, pp. 381- 388 ,(1968) , 10.1016/S0368-1319(68)80095-X
K. C. Samuel, Atherosclerosis and occlusion of the internal carotid artery The Journal of Pathology and Bacteriology. ,vol. 71, pp. 391- 401 ,(1956) , 10.1002/PATH.1700710214
R. Ross, J. Glomset, B. Kariya, L. Harker, A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro Proceedings of the National Academy of Sciences of the United States of America. ,vol. 71, pp. 1207- 1210 ,(1974) , 10.1073/PNAS.71.4.1207