Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster
作者： Ammon B Corl , Aylin R Rodan , Ulrike Heberlein
DOI: 10.1038/NN1363
关键词:
摘要: The insulin signaling pathway regulates multiple physiological processes, including energy metabolism, organismal growth, aging and reproduction. Here we show that genetic manipulations in Drosophila melanogaster impair the function of insulin-producing cells or insulin-receptor nervous system lead to increased sensitivity intoxicating effects ethanol. These findings suggest a previously unknown role for this highly conserved regulating behavioral responses an addictive drug.
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