An online database for brain disease research
作者： Brandon W Higgs , Michael Elashoff , Sam Richman , Beata Barci
关键词:
摘要: The Stanley Medical Research Institute online genomics database (SMRIDB) is a comprehensive web-based system for understanding the genetic effects of human brain disease (i.e. bipolar, schizophrenia, and depression). This contains fully annotated clinical metadata gene expression patterns generated within 12 controlled studies across 6 different microarray platforms. A thorough collection summaries are provided, inclusive patient demographics, subclasses, regulated biological pathways, functional classifications. combination content, structure, query speed offers researchers an efficient tool data mining complete with information such as: cross-platform comparisons, biomarkers elucidation target discovery, lifestyle/demographic associations to diseases.
biomedcentral.com
springer.com
doaj.org参考文章(11)
Paul Pavlidis, William S Noble, Analysis of strain and regional variation in gene expression in mouse brain Genome Biology. ,vol. 2, pp. 1- 15 ,(2001) , 10.1186/GB-2001-2-10-RESEARCH0042
Ashish Nimgaonkar, Despina Sanoudou, Atul J Butte, Judith N Haslett, Louis M Kunkel, Alan H Beggs, Isaac S Kohane, Reproducibility of Gene Expression Across Generations of Affymetrix Microarrays BMC Bioinformatics. ,vol. 4, pp. 27- 27 ,(2003) , 10.1186/1471-2105-4-27
Linda W. Jurata, Yury V. Bukhman, Vinod Charles, Frank Capriglione, Jeffrey Bullard, Andrew L. Lemire, Ali Mohammed, Quyen Pham, Pascal Laeng, Jeffrey A. Brockman, C.Anthony Altar, Comparison of microarray-based mRNA profiling technologies for identification of psychiatric disease and drug signatures. Journal of Neuroscience Methods. ,vol. 138, pp. 173- 188 ,(2004) , 10.1016/J.JNEUMETH.2004.04.002
Jae K Lee, Kimberly J Bussey, Fuad G Gwadry, William Reinhold, Gregory Riddick, Sandra L Pelletier, Satoshi Nishizuka, Gergely Szakacs, Jean-Phillipe Annereau, Uma Shankavaram, Samir Lababidi, Lawrence H Smith, Michael M Gottesman, John N Weinstein, Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells Genome Biology. ,vol. 4, pp. 1- 12 ,(2003) , 10.1186/GB-2003-4-12-R82
Nancy Mah, Anders Thelin, Tim Lu, Susanna Nikolaus, Tanja Kühbacher, Yesim Gurbuz, Holger Eickhoff, Günther Klöppel, Hans Lehrach, Björn Mellgård, Christine M. Costello, Stefan Schreiber, A comparison of oligonucleotide and cDNA-based microarray systems Physiological Genomics. ,vol. 16, pp. 361- 370 ,(2004) , 10.1152/PHYSIOLGENOMICS.00080.2003
H. Cho, J. K. Lee, Bayesian hierarchical error model for analysis of gene expression data Bioinformatics. ,vol. 20, pp. 2016- 2025 ,(2004) , 10.1093/BIOINFORMATICS/BTH192
Paul K Tan, Thomas J Downey, Edward L Spitznagel Jr, Pin Xu, Dadin Fu, Dimiter S Dimitrov, Richard A Lempicki, Bruce M Raaka, Margaret C Cam, Evaluation of gene expression measurements from commercial microarray platforms Nucleic Acids Research. ,vol. 31, pp. 5676- 5684 ,(2003) , 10.1093/NAR/GKG763
Jiang Li, Matthew Pankratz, Jeffrey A Johnson, Differential Gene Expression Patterns Revealed by Oligonucleotide Versus Long cDNA Arrays Toxicological Sciences. ,vol. 69, pp. 383- 390 ,(2002) , 10.1093/TOXSCI/69.2.383
Winston Patrick Kuo, Tor-Kristian Jenssen, Atul J Butte, Lucila Ohno-Machado, Isaac S Kohane, Analysis of matched mRNA measurements from two different microarray technologies Bioinformatics. ,vol. 18, pp. 405- 412 ,(2002) , 10.1093/BIOINFORMATICS/18.3.405
Brigham H Mecham, Gregory T Klus, Jeffrey Strovel, Meena Augustus, David Byrne, Peter Bozso, Daniel Z Wetmore, Thomas J Mariani, Isaac S Kohane, Zoltan Szallasi, Sequence‐matched probes produce increased cross‐platform consistency and more reproducible biological results in microarray‐based gene expression measurements Nucleic Acids Research. ,vol. 32, ,(2004) , 10.1093/NAR/GNH071