Voltammetric Behavior of a 4-Nitroimidazole Derivative Nitro Radical Anion Formation and Stability

摘要: A new synthesized compound, l-methyl-4-nitro-2-hydroxymethylimidazole (4-MNImOH), was electrochemically reduced at the mercury electrode in aqueous, mixed, and aprotic media. In an aqueous medium, only one voltammetric peak observed because of four-electron, four-proton reduction nitro group to hydroxylamine derivative 2-12 pH range. For mixed nonaqueous media, it possible observe a reversible couple due first one-electron step radical anion.The anion decays by disproportionation reaction media dimerization medium. Both rate constants, k 2 , were determined according Olmstead's approach, obtaining value 1460 ′ 110 M - 1 s values dependent both on nature cosolvent.After comparison 4-MNImOH with parent 4-nitroimidazole, we concluded that substitution 1-methyl 2-hydroxymethyl produces more easily reducible compound less stable than unsubstituted 4-nitroimidazole. According electrochemical results, would be suitable for enzymatic toxic host