Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts.

摘要: Nude mice were challenged with human U-87 MG glioblastoma tumors to assess the efficacy of different cytostatics and application protocols. While intraperitoneal BCNU solutions (3 times 20 mg BCNU/kg) had no effect on tumor growth, polymer matrices made a physical mixture poly(1,3-bis[carboxyphenoxpropane]-co-sebacic acid) 20:80 poly(Image,Image-lactic-co-glycolic loaded 0.25 BCNU, slowed down growth significantly. When animals treated implants carrying they responded treatment whether been inoculated recently (9 days ago) or it was fully established (after days). After its sensitivity proven, xenograft model used further investigate anticancer drugs some regimens using implants. Thus allowed discriminate between doses BCNU. Only 0.75 1 led substantial suppression over approximately 2 months. only able suppress tumor, combination paclitaxel complete remission in animals. These preliminary results suggest that combinations might improve local chemotherapy malignant glioma substantially. Based our data will be worthwhile release such as closer. Amongst other factors we try elucidate repetitive programmable