Atrial fibrillation driver mechanisms: Insight from the isolated human heart
作者： Thomas A. Csepe , Brian J. Hansen , Vadim V. Fedorov
DOI: 10.1016/J.TCM.2016.05.008
关键词:
摘要: Although there have been great technological advances in the treatment of atrial fibrillation (AF), current therapies remain limited due to a narrow understanding AF mechanisms human heart. This review will highlight our recent studies on explanted hearts where we developed and employed novel functional-structural mapping approach by integrating high-resolution simultaneous endo-epicardial panoramic optical with 3D gadolinium-enhanced MRI define spatiotemporal characteristics drivers their structural substrates. The results allow us postulate that primary mechanism maintenance is number localized intramural microanatomic reentrant anchored heart-specific fibrotically insulated myobundle tracks, which may hidden clinical single-surface electrode mapping. We suggest ex vivo heart studies, using an integrated functional approach, help reveal defining features as well validate improve approaches detect target these patients cardiac diseases.
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