Elemental Constituents of Particulate Matter and Newborn’s Size in Eight European Cohorts

摘要: Background: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to constituents PM and newborn’s size have been little examined. Objective: We aimed investigate the associations elemental with term low birth weight (LBW; < 2,500 g among births after 37 weeks gestation), mean weight, head circumference, relying standardized fine-scale assessment extensive control for potential confounders. Methods: pooled data from eight European cohorts comprising 34,923 singleton in 1994-2008. Annual average concentrations ≤ 2.5 10 μm (PM2.5 PM10) at home addresses during pregnancy were estimated using land-use regression models. Adjusted each measurement elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) calculated random-effects data. Results: A 200-ng/m3 increase sulfur PM2.5 was associated an increased risk LBW (adjusted odds ratio = 1.36; 95% confidence interval: 1.17, 1.58). Increased nickel zinc also LBW. Head circumference reduced higher all except potassium. All most robust adjustment mass concentration. results similar PM10. conclusion: Sulfur, reflecting secondary combustion particles this study, adversely affect independently particle mass. © 2015, Public Health Services, US Dept Human Services. rights reserved.