The Potential of Epigenetic Compounds in Treating Diabetes

作者: Steven G. Gray

DOI: 10.1016/B978-0-12-388415-2.00017-2

关键词:

摘要: Abstract Globally, diabetes (and in particular type 2 diabetes) continues to present as a major health challenge worldwide. Despite our efforts, understanding of the genetic events underpinning pathogenesis remains poor. Altered epigenetics has, however, been firmly associated with many aspects critical pathogenesis, and increased this area has resulted identification several therapeutic options potential for management diabetes. This chapter outlines how is altered diabetes, may contribute summarizes targeting have significant benefit treatment condition.

参考文章(351)
Quintin J Quinones, Salvatore V Pizzo, Gustaaf G de Ridder, GRP78, A chaperone with diverse roles beyond the endoplasmic reticulum Histology and Histopathology. ,vol. 23, pp. 1409- 1416 ,(2008) , 10.14670/HH-23.1409
Michael L. Mulhern, Peter F. Kador, Toshimichi Shinohara, Christian J. Madson, James Randazzo, Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats. Molecular Vision. ,vol. 13, pp. 1397- 1405 ,(2007)
Marie-Elaine Caruso, Eric Chevet, Systems Biology of the Endoplasmic Reticulum Stress Response Sub-cellular biochemistry. ,vol. 43, pp. 277- 298 ,(2007) , 10.1007/978-1-4020-5943-8_13
Srinivasan M, Effect of curcumin on blood sugar as seen in a diabetic subject. Indian Journal of Medical Sciences. ,vol. 26, pp. 269- 270 ,(1972)
S E Shoelson, J Lee, M Yuan, Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance International Journal of Obesity. ,vol. 27, ,(2003) , 10.1038/SJ.IJO.0802501
Deepti Ramachandran, Upasana Roy, Swati Garg, Sanchari Ghosh, Sulabha Pathak, Ullas Kolthur-Seetharam, Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets FEBS Journal. ,vol. 278, pp. 1167- 1174 ,(2011) , 10.1111/J.1742-4658.2011.08042.X
Muller Fabbri, George A. Calin, Epigenetics and miRNAs in human cancer. Advances in Genetics. ,vol. 70, pp. 87- 99 ,(2010) , 10.1016/B978-0-12-380866-0.60004-6
Dongsheng Cai, Minsheng Yuan, Daniel F Frantz, Peter A Melendez, Lone Hansen, Jongsoon Lee, Steven E Shoelson, Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB Nature Medicine. ,vol. 11, pp. 183- 190 ,(2005) , 10.1038/NM1166
Kristian Tveten, Øystein L. Holla, Trine Ranheim, Knut E. Berge, Trond P. Leren, Mari A. Kulseth, 4-Phenylbutyrate restores the functionality of a misfolded mutant low-density lipoprotein receptor. FEBS Journal. ,vol. 274, pp. 1881- 1893 ,(2007) , 10.1111/J.1742-4658.2007.05735.X