Theoretical Considerations in Developing Amorphous Solid Dispersions

摘要: Before pursuing the laborious route of amorphous solid dispersion formulation and development, which is topic many subsequent chapters in this book, scientist would benefit from a priori knowledge whether viable one for given drug how much solubility improvement, hence increase bioavailability, can be expected, what forms have been developed past. In chapter, we therefore initially define various dispersions, then go on to discuss properties pure drugs with respect their glass-forming ability glass stability. main parts review theoretical approaches determine polymer miscibility crystalline solubility, as prerequisite develop dispersions (glass solutions).