XPA gene, its product and biological roles.

摘要: The 31kDa XPA protein is part of the core incision complex mammalian nucleotide excision repair (NER) system and interacts with DNA as well many other NER subunits. In absence XPA, no can form damaged damage occurs. A comparative analysis DNA-binding properties in presence different substrate conformations indicated that preferentially kinked backbones. domain displays a positively charged cleft involved an indirect readout mechanism, presumably by detecting increased negative potential encountered at sharp bends. We propose this recognition function contributes to verification probing susceptibility be during assembly complexes.