Oral vaccination of wildlife against rabies: Differences among host species in vaccine uptake efficiency.

摘要: Oral vaccination using attenuated and recombinant rabies vaccines has been proven a powerful tool to combat in wildlife. However, clear differences have observed vaccine titers needed induce protective immune response against after oral different reservoir species. The mechanisms contributing the resistance some species are not completely understood. Hence, immunogenicity of virus strain, SPBN GASGAS, was investigated considered be susceptible (red fox) refractory this route administration (striped skunk). Additionally, dissemination cavity analyzed for these two It shown that palatine tonsils play critical role uptake. Main could tonsil infection between both species, revealing locally restricted infected cells foxes. absence skunks suggests less efficient uptake or by which may lead reduced vaccination. Understanding absorption primary replication development novel strategies enhance efficacy problematic like striped skunk.