The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model

摘要: Functional short tandem repeats (STR) are polymorphic in the population, and number of regulates expression nearby genes (known as STR, eSTR). STR IGF1 promoter has been extensively studied for its association with concentration blood various clinical traits represents an important eSTR. We previously used in-vitro luciferase reporter model to examine interaction between STRs SNPs promoter. Here, we further explored mechanism how gene transcription. An inverse correlation extent transactivation was found a haplotype consisting three (C-STR-T-T). showed that these adjacent located outside were required function The C allele rs35767 provides binding site CCAAT/enhancer-binding-protein δ (C/EBPD), which is essential gradational property eSTR FOXA3 may also be involved. Therefore, propose by caused one or more transcriptional complexes rather than direct repeat motif STR.