An aptamer-functionalized chemomechanically modulated biomolecule catch-and-release system

作者: Ankita Shastri , Lynn M. McGregor , Ya Liu , Valerie Harris , Hanqing Nan

DOI: 10.1038/NCHEM.2203

关键词:

摘要: The efficient extraction of (bio) molecules from fluid mixtures is vital for applications ranging from target characterization in (bio) chemistry to environmental analysis and biomedical diagnostics. Inspired by biological processes that seamlessly synchronize the capture, transport and release of biomolecules, we designed a robust chemomechanical sorting system capable of the concerted catch and release of target biomolecules from a solution mixture. The hybrid system is composed of target-specific, reversible binding sites attached …

参考文章(49)
Louis C. Bock, Linda C. Griffin, John A. Latham, Eric H. Vermaas, John J. Toole, Selection of single-stranded DNA molecules that bind and inhibit human thrombin. Nature. ,vol. 355, pp. 564- 566 ,(1992) , 10.1038/355564A0
Renee K. Mosing, Michael T. Bowser, Microfluidic selection and applications of aptamers Journal of Separation Science. ,vol. 30, pp. 1420- 1426 ,(2007) , 10.1002/JSSC.200600483
Li Chen, Xueli Liu, Bin Su, Jing Li, Lei Jiang, Dong Han, Shutao Wang, None, Aptamer‐Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces Advanced Materials. ,vol. 23, pp. 4376- 4380 ,(2011) , 10.1002/ADMA.201102435
Tibor Hianik, Veronika Ostatná, Michaela Sonlajtnerova, Igor Grman, Influence of ionic strength, pH and aptamer configuration for binding affinity to thrombin Bioelectrochemistry. ,vol. 70, pp. 127- 133 ,(2007) , 10.1016/J.BIOELECHEM.2006.03.012
Tao Li, Lili Shi, Erkang Wang, Shaojun Dong, Multifunctional G-Quadruplex Aptamers and Their Application to Protein Detection Chemistry: A European Journal. ,vol. 15, pp. 1036- 1042 ,(2009) , 10.1002/CHEM.200801282
Heike Schürer, Katherina Stembera, Dietmar Knoll, Günter Mayer, Michael Blind, Hans-Heinrich Förster, Michael Famulok, Peter Welzel, Ulrich Hahn, None, Aptamers that bind to the antibiotic moenomycin A Bioorganic & Medicinal Chemistry. ,vol. 9, pp. 2557- 2563 ,(2001) , 10.1016/S0968-0896(01)00030-X
Roie Yerushalmi, Avigdor Scherz, Milko E. van der Boom, Heinz-Bernhard Kraatz, Stimuli responsive materials: new avenues toward smart organic devices Journal of Materials Chemistry. ,vol. 15, pp. 4480- 4487 ,(2005) , 10.1039/B505212B
Takahiro Arakawa, Yoshitaka Shirasaki, Tokihiko Aoki, Takashi Funatsu, Shuichi Shoji, None, Three-dimensional sheath flow sorting microsystem using thermosensitive hydrogel Sensors and Actuators A-physical. ,vol. 135, pp. 99- 105 ,(2007) , 10.1016/J.SNA.2006.06.074
Lawrence W. Dick, Linda B. McGown, Aptamer-enhanced laser desorption/ionization for affinity mass spectrometry. Analytical Chemistry. ,vol. 76, pp. 3037- 3041 ,(2004) , 10.1021/AC049860E
Elisha Krieg, Haim Weissman, Elijah Shirman, Eyal Shimoni, Boris Rybtchinski, A recyclable supramolecular membrane for size-selective separation of nanoparticles Nature Nanotechnology. ,vol. 6, pp. 141- 146 ,(2011) , 10.1038/NNANO.2010.274