Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors
作者： Bruno Ramos-Molina , Adam N Lick , Amir Nasrolahi Shirazi , Donghoon Oh , Rakesh Tiwari
DOI: 10.1371/JOURNAL.PONE.0130417
关键词:
摘要: Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types cargoes, such as drugs and proteins. These reagents are chemically similar multi-basic that known be potent proprotein convertase inhibitors. Here, we report both HIV-1 TAT47-57 peptide Chariot reagent micromolar inhibitors furin activity in vitro. In agreement, reduced HT1080 cell migration, thought mediated by convertases, 25%. addition, cyclic polyarginine containing hydrophobic moieties which previously transfection also exhibited inhibition vitro inhibited convertases. Our finding cationic exert effects on cellular should taken into account when biological assessed.
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