Remote alkylation of N-(quinolin-8-yl)benzamides with alkyl bromides via ruthenium(II)-catalyzed C–H bond activation
作者： Arumugam Mariappan , Krishna Mohan Das , Masilamani Jeganmohan
DOI: 10.1039/C8OB00581H
关键词:
摘要: A ruthenium(II) catalyzed remote C-5 alkylation of the quinoline ring N-(quinolin-8-yl)benzamides with alkyl bromides via C–H bond activation is described. Various substituted reacted tertiary or secondary primary giving alkylated products in good to moderate yields. Herein, ruthenium effected aromatic as a key step. It has been proved by deuterium labelling studies and mechanistic investigations.
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