Supercritical Fluids Crystallization of Budesonide and Flunisolide

作者: Sitaram P. Velaga , Rolf Berger , Johan Carlfors

DOI: 10.1023/A:1020477204512

关键词:

摘要: … the formation of polymorphic mixtures at 80C and a new polymorph III at … polymorphs of flunisolide were produced. Particle characteristics were controlled by the temperature, pressure …

参考文章(15)
A. Kordikowski, T. Shekunov, P. York, Polymorph control of sulfathiazole in supercritical CO2. Pharmaceutical Research. ,vol. 18, pp. 682- 688 ,(2001) , 10.1023/A:1011045729706
Azita Saleki-Gerhardt, Claes Ahlneck, George Zografi, Assessment of disorder in crystalline solids International Journal of Pharmaceutics. ,vol. 101, pp. 237- 247 ,(1994) , 10.1016/0378-5173(94)90219-4
John Haleblian, Walter McCrone, Pharmaceutical Applications of Polymorphism Journal of Pharmaceutical Sciences. ,vol. 58, pp. 911- 929 ,(1969) , 10.1002/JPS.2600580802
M. Rehman, B.Y. Shekunov, P. York, P. Colthorpe, Solubility and Precipitation of Nicotinic Acid in Supercritical Carbon Dioxide Journal of Pharmaceutical Sciences. ,vol. 90, pp. 1570- 1582 ,(2001) , 10.1002/JPS.1107
Jean W. Tom, Pablo G. Debenedetti, Particle formation with supercritical fluids—a review Journal of Aerosol Science. ,vol. 22, pp. 555- 584 ,(1991) , 10.1016/0021-8502(91)90013-8
H. Steckel, J. Thies, B.W. Müller, Micronizing of steroids for pulmonary delivery by supercritical carbon dioxide International Journal of Pharmaceutics. ,vol. 152, pp. 99- 110 ,(1997) , 10.1016/S0378-5173(97)00071-9
M Bartolomei, Solid-state studies on the hemihydrate and the anhydrous forms of flunisolide. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 24, pp. 81- 93 ,(2000) , 10.1016/S0731-7085(00)00390-3
B.Yu Shekunov, M Hanna, P York, Crystallization process in turbulent supercritical flows Journal of Crystal Growth. ,vol. 198, pp. 1345- 1351 ,(1999) , 10.1016/S0022-0248(98)01022-7
Steve Beach, David Latham, Colin Sidgwick, Mazen Hanna, Peter York, Control of the Physical Form of Salmeterol Xinafoate Organic Process Research & Development. ,vol. 3, pp. 370- 376 ,(1999) , 10.1021/OP990160Z
B. Yu. Shekunov, J. Baldyga, P. York, Particle formation by mixing with supercritical antisolvent at high Reynolds numbers. Chemical Engineering Science. ,vol. 56, pp. 2421- 2433 ,(2001) , 10.1016/S0009-2509(00)00443-7