Phage fitness may help predict phage therapy efficacy

摘要: We isolated 6 phages from 2 environmental water sources and assessed their ability to treat Pseudomonas aeruginosa infection of Drosophila melanogaster. found all were able significantly increase mean survival time (MST) infected D. Although phage traits, such as adsorption rate, burst size, lysis time, varied among these phages, none the traits correlated with MST. Phage growth rate determined in vitro, however, was be Overall, our study shows that melanogaster can used a model system test therapeutic efficacy phages. In addition, more comprehensive characteristic, like vitro seems better indicator predicting success than constituent or time.