Cholinesterase Inhibitors Do More than Inhibit Cholinesterase

摘要: The cholinergic system plays an important role in learning and memory processes. crucial of acetylcholine (ACh) is supported by three lines evidence. first line the effects pharmacological manipulation using agonists or antagonists at both nicotinic muscarinic receptors (Decker McGaugh, 1991; Murray Fibiger, 1985; Mandel Thal, 1988; et al., 1989; Drachman Leavitt, 1974; Drachman, 1982; Flicker 1992; Vanderwolf 1990; Wesnes 1990). Second fact that adverse lesioning nuclei are ameliorated intracerebral transplantation fetal cells genetically modified tissue (Alkon Dekker Page Berger- Sweeney 1994; Dunnett Gage Bjorklund, 1986; Nilsson 1987). third deficits cortical innervation decreases seen humans during aging Alzheimer’s disease (AD) (Perry 1978; Whitehouse Bartus Giacobini Schroder 1995). Results from these investigations consistent with concept function required for memory. A recent article Winkler al. (1995) demonstrates cerebral ACh not only necessary cognitive behavior rat but its presence within neocortex also sufficient to improve restore experimental animals following severe damage nucleus basalis Meynert.