Association between MYH9 and APOL1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes in a Chinese Han Population.
作者： Hailing Zhao , Liang Ma , Meihua Yan , Yan Wang , Tingting Zhao
DOI: 10.1155/2018/5068578
关键词:
摘要: Single-nucleotide polymorphisms (SNPs) in MYH9-APOL1 gene regions have been reported to be associated with diabetic kidney disease (DKD) the American population. We examined association between and DKD susceptibility a Chinese Han MYH9 rs3752462 (T>C) APOL1 rs136161 (C>G) were genotyped 303 patients 364 type 2 diabetes mellitus (T2DM) without using TaqMan SNP genotyping assay. Chi-squared test multivariate logistic regression used evaluate association. observed that only was (genotype, P = 0.004; allele, 0.002). Genetic model analysis revealed increased risk of under dominant adjusted by age sex (adjusted odds ratio (aOR), 1.675; 95% CI 1.225-2.289; 0.001) an additive (TC versus TT: aOR, 1.649; 1.187-2.290; CC 1.817; 0.980-3.367; 0.005). The combined effect TC + rs136161 genotype showed (aOR, 1.732; 1.128-2.660; 0.012). After Holm-Bonferroni correction for multiple tests, C allele frequencies TC + CC considered statistically significant markedly (P < 0.00208; Our results suggest is significantly individuals.
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