Pediatric Malignancies: Retinoblastoma and Wilms’ Tumor

作者: David A. Sweetser , Eric F. Grabowski

DOI: 10.1007/978-0-387-93846-2_12

关键词:

摘要: Retinoblastoma and Wilms’ tumor represent two childhood tumors with both sporadic familial forms. Delineation of the molecular etiology these cancers identified retinoblastoma gene Rb as first example a suppressor provided imprinting cancer predisposition in tumor. In this chapter, we review clinical features genetics disorders implications for management, early detection potential prevention disorders.

参考文章(187)
T P Dryja, T L McGee, T M Nork, T L Schwartz, J Rapaport, Molecular etiology of low-penetrance retinoblastoma in two pedigrees. American Journal of Human Genetics. ,vol. 52, pp. 1122- 1128 ,(1993)
H P Klinger, D A Miller, D Warburton, C A Abrams, O J Miller, P W Allderdice, F H Allen, E McGilvray, J G Davis, The 13q-deletion syndrome. American Journal of Human Genetics. ,vol. 21, pp. 499- 512 ,(1969)
Madge T. Macklin, A study of retinoblastoma in Ohio. American Journal of Human Genetics. ,vol. 12, pp. 1- 43 ,(1960)
A P Feinberg, M Boehnke, M R Young, D J Law, A E Reeve, A J Ping, Genetic linkage of Beckwith-Wiedemann syndrome to 11p15. American Journal of Human Genetics. ,vol. 44, pp. 720- 723 ,(1989)
Louise C Strong, A. G. Knudson, Letter: Familial Wilms's tumor. American Journal of Human Genetics. ,vol. 27, pp. 809- 810 ,(1975)
N Raben, R Exelbert, R C Nichols, F W Miller, P H Plotz, C Nicastri, C F Boerkoel, Leaky splicing mutation in the acid maltase gene is associated with delayed onset of glycogenosis type II. American Journal of Human Genetics. ,vol. 56, pp. 887- 897 ,(1995)
Stuart H. Orkin, Oncology of infancy and childhood Saunders Elsevier. ,(2009)
D W Yandell, T P Dryja, Detection of DNA sequence polymorphisms by enzymatic amplification and direct genomic sequencing. American Journal of Human Genetics. ,vol. 45, pp. 547- 555 ,(1989)
J. William Harbour, Douglas C. Dean, Rb function in cell-cycle regulation and apoptosis Nature Cell Biology. ,vol. 2, ,(2000) , 10.1038/35008695
Perry E. Telzerow, Vicki Huff, Paul E. Grundy, Jamie Moksness, Malcolm C. Paterson, Norman Breslow, Loss of heterozygosity for chromosomes 16q and 1p in Wilms' tumors predicts an adverse outcome Cancer Research. ,vol. 54, pp. 2331- 2333 ,(1994)