作者: David A. Sweetser , Eric F. Grabowski
DOI: 10.1007/978-0-387-93846-2_12
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摘要: Retinoblastoma and Wilms’ tumor represent two childhood tumors with both sporadic familial forms. Delineation of the molecular etiology these cancers identified retinoblastoma gene Rb as first example a suppressor provided imprinting cancer predisposition in tumor. In this chapter, we review clinical features genetics disorders implications for management, early detection potential prevention disorders.