Down Syndrome as a Special Case of Oxidatively Induced Developmental Dysregulation

摘要: Down syndrome (DS), trisomy 21, is the most common genetic form of intellectual disability. Life expectancy for DS population has improved, although with increasing age, pathological dysfunctions are exacerbated and disability degenerates in cases a dementia that closely resembles Alzheimer disease (AD). The neuropathology results from combination several factors among which free radical metabolism mitochondrial function key players major contributors to neuronal degeneration. Indeed, many genes encoded by chromosome 21 responsible increased oxidative stress (OS) conditions also result as consequence decreased antioxidant defense further exaggerated presence dysfunction.