Anti-insulin antibodies and birth weight in pregnancies complicated by diabetes
作者： Peter A.M Weiss , Franz Kainer , Peter Pürstner , Gerda Zehetleitner , Ulla Hüttner
DOI: 10.1016/S0378-3782(98)00047-4
关键词:
摘要: Free insulin cannot cross the placenta but complexed to anti-insulin antibodies has been demonstrated in cord blood. We studied whether antibody-bound diabetic patients can evoke fetal macrosomia independently of maternal metabolic control. In 457 non insulin-treated controls and 173 we measured 1187 antibody levels blood glucose, fructosamine, insulin, C-peptide, fructosamine amniotic fluid insulin. Mean were significantly higher treated (4.6 5.4 U/ml) than (1.8 1.7 with maxima 89.2 120.0 U/ml blood, respectively. 16.6% (maternal blood) 22% (cord above 97th percentile. There was a high significant correlation between (R = 0.987, P < 0.0001), no (glucose, fructosamine) or (insulin, insulin) parameters. While parameters correlated birth weight neither nor weight. These findings do not support hypothesis that influence
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Peter A.M. Weiss, Hannes M.H. Hofmann, Franz Kainer, Josef G. Haas, Fetal outcome in gestational diabetes with elevated amniotic fluid insulin levels Diabetes Research and Clinical Practice. ,vol. 5, pp. 1- 7 ,(1988) , 10.1016/S0168-8227(88)80071-8
W. A. Bauman, R. S. Yalow, Transplacental passage of insulin complexed to antibody Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 4588- 4590 ,(1981) , 10.1073/PNAS.78.7.4588
Robert Schwartz, Hyperinsulinemia and Macrosomia New England Journal of Medicine. ,vol. 323, pp. 340- 342 ,(1990) , 10.1056/NEJM199008023230512
U. Di Mario, F. Fallucca, P. Gargiulo, C. Tiberti, A. Scardellato, P. Arduini, A. Pachi', D. Andreani, Insulin-anti-insulin complexes in diabetic women and their neonates Diabetologia. ,vol. 27, pp. 83- 86 ,(1984) , 10.1007/BF00275654
U Roll, MR Christie, B Hillebrand, W Rabl, AG Ziegler, On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth Diabetologia. ,vol. 36, pp. 402- 408 ,(1993) , 10.1007/BF00402275
Ram K. Menon, Robert M. Cohen, Mark A. Sperling, Wayne S. Cutfield, Francis Mimouni, Jane C. Khoury, Transplacental Passage of Insulin in Pregnant Women with Insulin-Dependent Diabetes Mellitus New England Journal of Medicine. ,vol. 323, pp. 309- 315 ,(1990) , 10.1056/NEJM199008023230505
H. G. Velcovsky, K. F. Federlin, Insulin-specific IgG and IgE antibody response in type I diabetic subjects exclusively treated with human insulin (recombinant DNA). Diabetes Care. ,vol. 5, pp. 126- 128 ,(1982) , 10.2337/DIACARE.5.2.S126
Hannes M.H. Hofmann, Peter A.M. Weiss, Peter Pürstner, Josef Haas, Guenther Gmoser, Karl Tamussino, Barbara Schmon, Serum fructosamine and amniotic fluid insulin levels inpatients with gestational diabetes and healthy control subjects American Journal of Obstetrics and Gynecology. ,vol. 162, pp. 1174- 1177 ,(1990) , 10.1016/0002-9378(90)90010-5
P. A. M. WEISS, W. LICHTENEGGER, R. WINTER, P. PÜRSTNER, Insulin levels in amniotic fluid. Management of pregnancy in diabetes. Obstetrics & Gynecology. ,vol. 51, pp. 393- 398 ,(1978) , 10.1097/00006250-197804000-00002
E. ALBERT REECE, COLlN SMIKLE, THERESA Z. OʼCONNOR, THEODORE HOLFORD, LlSA NELSON-ROBINSON, NANCY DEGENNARO, JOHN C. HOBBINS, A longitudinal study comparing growth in diabetic pregnancies with growth in normal gestations: I. The fetal weight. Obstetrical & Gynecological Survey. ,vol. 45, pp. 161- ,(1990) , 10.1097/00006254-199003000-00003