Serratia type pore forming toxins.

摘要: The Serratia marcescens hemolysin represents a new type of and has been studied in great molecular detail with regard to structure, activation secretion. It nothing common the pore forming toxins E. coli (RTX toxins), Staphylococcus aureus alpha-toxin or thiol activated toxin group A beta-hemolytic streptococci (Streptolysin O). Studies on erythrocytes, eukaryotic cells artificial black lipid membranes, have shown that mechanism formation ShlA is different form other toxins. S. proteins ShlB exhibit protein sequence homologues Proteus mirabilis, Haemophilus ducreyi, Edwardsiella tarda Erwinia chrysantemi. Furthermore, motifs present Shlb be important for activity secretion hemolysin. Thus, forms prototype class hemolysins secretory mechanism. uniqueness this underlined by fact strictly requires phosphatidylethanolamine as cofactor. New data implicate conformational change during activation. In addition, not only pores erythrocytes but also fibroblasts epithelial cells. cytotoxic action mainly determined lysis infected vitro. sublytic doses, will normally situation vivo, exerts additionally effects which are currently under investigation. knowledge activation, mode implications proteins, related