Gastrointestinal stromal tumours (GIST)

摘要: Background-aim Gastrointestinal stromal tumours (GIST) are the most common mesenchymal neoplasms of gastrointestinal tract, yet extremely rare since they account for less than 1% all GI tumours, which may arise virtually in any part tract. GISTs typically defined as a group heterogeneous that characterized by expression c-KIT receptor tyrosine kinase (called CD117 antigen) and often also CD34 antigen. There is an equal gender distribution, with peak incidence between fifth sixth decade life. Twenty percent asymptomatic. Clinical symptoms non-specific including abdominal pain, ileus weight loss, while symptom at presentation bleeding. Due to presenting symptoms, diagnosis GIST delayed. Useful diagnostic tools include imaging, endoscopy histological examinations. prone metastasize. Prognostic factors tumour size, mitotic activity location. The optimal treatment radical surgery, inhibitor imatinib has significantly improved outcome disease. In current study, we present five cases treated our department during period 2007–2009, followed brief review literature.