Recombinant dna molecules, process for their production, their use for production of hepatitis b surface antigen (hbsag) and pharmaceutical compositions containing this hbsag

摘要: Described are a) recombinatn DNA molecules containing a fragment from Hepatitis B Virus comprising the structu­ ral gene of surface antigen; b) recombinant cloning vehicles said molecules; c) microbial hosts cloning vehi­ cles; d) genomes or parts thereof animal viruses as eukary­ otic vectors recombinant for selection vertebrate cells and expression at least one Hepatits antigen in the selected cells; e) established cell lines continu­ ously producing a nutrient medium large amounts one which is released into nu­ trient medium; f) compositions Hepati­ tis produced by stimulat­ ing production antibodies humans to infection detecting infection antibod­ ies Virus.