Efficacy of steroid addition to multimodal cocktail periarticular injection in total knee arthroplasty: a meta-analysis.

摘要: Total knee arthroplasty (TKA) has been reported to be the most successful treatment for patients with advanced osteoarthritis, however, early postoperative pain become an unresolved issue. The aim of this Meta-analysis is evaluate efficacy and safety steroid addition multimodal cocktail periarticular injection (MCPI) in undergoing TKA. Clinical randomized controlled trials concerning MCPI containing steroids TKA published up December 2014 were retrieved from PubMed, Cochrane library, EMbase databases. methodological quality included studies was assessed by 12-item scale. Data analysis performed using StataSE12.0. Six involving a total 567 assessed; group 305 patients, control 262 patients. meta-analysis showed that significantly reduced pain; duration time required perform straight-leg raising length hospital stay (P 0.05). For safety, did not increase incidence infection wound oozing >0.05); no tendon rupture now. In addition, decrease drainage through reduction prostaglandins >0.05). TKA, improved analgesic effect proved highly safe. reduced. However, neither increased range motion (ROM) or long-term ROM knee, nor it reduce drainage. best results are acquired without any altered immunological status.