Effects of combining methylprednisolone with magnesium sulfate on neuropathic pain and functional recovery following spinal cord injury in male rats.
作者： Mahsa Ghajarzadeh , Abbas Norouzi-Javidan , Leila Farsi , Mansoor Keshavarz , Zeinab Naghshband
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摘要: Methylprednisolone (MP) has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (SCI). Because its controversial useful effects, combination MP and other pharmacological agents to enhance neuroprotective effects is desirable. Magnesium sulfate (MgSO4) shown have antihyperalgesic effects. In present study, we sought determine effect combining MgSO4, on neuropathic pain functional recovery following (SCI) in male rats. A total 48 adult rats (weight 300-350 g) were used. After laminectomy, complete SCI was achieved by compression one minute with aneurysm clips. Single doses (MgSO4), (600 mg/kg), (MP), (30 mg/kg) or MgSO4 injected intraperitoneally. Prior surgery during four weeks study Tail flick latency (TFL) BBB (Basso-Beattie-Bresnahan) score acetone drop test evaluated. mean values score, significant difference observed SCI+veh compared groups (P<0.05). Mean TFL also significantly higher weight different MP treated group These findings revealed that MP, can attenuate pains include: thermal hyperalgesia cold allodynia. They yield better improvement motor function decrease loss after control group.
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