SOG1-dependent NAC103 modulates the DNA damage response as a transcriptional regulator in Arabidopsis.
作者： Tae Ho Ryu , Young Sam Go , Seung Hee Choi , Jeong‐Il Kim , Byung Yeoup Chung
DOI: 10.1111/TPJ.14201
关键词:
摘要: The plant-specific transcription factor (TF) NAC103 was previously reported to modulate the unfolded protein response in Arabidopsis under endoplasmic reticulum (ER) stress. Alternatively, we report here that is involved downstream signaling of SOG1, a master regulator for expression DNA damage (DDR) genes induced by genotoxic strongly stress and nac103 mutants displayed substantial inhibition DDR gene after gamma radiation or radiomimetic zeocin treatment. phenotypes, such as true leaf inhibition, root cell death growth were also suppressed significantly mutants, but lesser extent than sog1-1 mutant. By contrast, overexpression increased without substantially rescued phenotypic changes mutant putative promoters some representative genes, RAD51, PARP1, RPA1E, BRCA1 At4g22960, found partly interact with NAC103. Together expected interaction SOG1 promoter NAC103, our study suggests SOG1-dependent transcriptional plant which are responsible phenotypes
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