Clinical trials in lung cancer surgery and research cooperation.

作者: Wen-Zhao Zhong , Yi-Long Wu , Hao-Ran Zhai

DOI: 10.21037/CCO.V3I4.5051

关键词:

摘要: Background: With China having an increasingly huge burden of lung cancers, the number Chinese studies was second largest all over world. Methods: We used advanced search option available on ClinicalTrials.gov to review clinical trials regarding surgical issues. In drop down menus, we chose “all studies” for recruitment status and “interventional” study type reported until Aug, 2013 website were included. Results: Clinical cancer surgeries (658 records) mainly aim at procedures (neo)adjuvant studies, among which phase III account 15.5%. Only 34.9% (230 completed, 43 presented their results . The median time completion (MTC) procedure is 9.4 years. MTCs neo-adjuvant adjuvant have not been reached, but definitely are longer than 10 comparison, MTC in first-line treatment only 4.3 years. Comments: summarized characteristics these using real-world case examples. Our analyses reveal that it critically needed regulatory authorities, trial sponsors, collaborative research groups, academic institutions work together build up infrastructure cooperation with a component. 2007, national group, Thoracic Oncology Group (CTONG), established. CTONG network researchers, physicians health-care professionals public throughout currently has growing membership 25 hospitals. A CTONG-sponsored (CTONG1104) discussed illustrate our experience trials. summary, imperative investigators collaborate cooperative order expedite applications therapies from researches treatment. Since multidisciplinary, current should multiple combinations while retaining focus, be carried out systematically extensive monitoring coordinating systems.

参考文章(16)
Janakiraman Subramanian, Thomas Regenbogen, Gayathri Nagaraj, Alex Lane, Siddhartha Devarakonda, Gongfu Zhou, Ramaswamy Govindan, Review of Ongoing Clinical Trials in Non–Small-Cell Lung Cancer: A Status Report for 2012 from the ClinicalTrials.gov Web Site Journal of Thoracic Oncology. ,vol. 8, pp. 860- 865 ,(2010) , 10.1097/JTO.0B013E318287C562
Moritz N. Wente, Christoph M. Seiler, Waldemar Uhl, Markus W. Büchler, Perspectives of Evidence-Based Surgery Digestive Surgery. ,vol. 20, pp. 263- 269 ,(2003) , 10.1159/000071183
Heather Wakelee, Kemp Kernstine, Everett Vokes, Joan Schiller, Paul Baas, Nagahiro Saijo, Alex Adjei, Glenwood Goss, Laurie Gaspar, David R. Gandara, Hak Choy, Joe “Bill” Putnam, Cooperative Group Research Efforts in Lung Cancer 2008: Focus on Advanced-Stage Non–Small-Cell Lung Cancer Clinical Lung Cancer. ,vol. 9, pp. 346- 351 ,(2008) , 10.3816/CLC.2008.N.050
Ken A Olaussen, Ariane Dunant, Pierre Fouret, Elisabeth Brambilla, Fabrice André, Vincent Haddad, Estelle Taranchon, Martin Filipits, Robert Pirker, Helmut H Popper, Rolf Stahel, Laure Sabatier, Jean-Pierre Pignon, Thomas Tursz, Thierry Le Chevalier, Jean-Charles Soria, None, DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. The New England Journal of Medicine. ,vol. 355, pp. 983- 991 ,(2006) , 10.1056/NEJMOA060570
Tetsuya Mitsudomi, Kenichi Suda, Yasushi Yatabe, Surgery for NSCLC in the era of personalized medicine Nature Reviews Clinical Oncology. ,vol. 10, pp. 235- 244 ,(2013) , 10.1038/NRCLINONC.2013.22
Heather Wakelee, Corey Langer, Everett Vokes, Joan Schiller, Paul Baas, Nagahiro Saijo, Alex Adjei, Frances Shepherd, Hak Choy, David R. Gandara, Cooperative group research efforts in lung cancer: focus on early-stage non-small-cell lung cancer Clinical Lung Cancer. ,vol. 9, pp. 9- 15 ,(2008) , 10.3816/CLC.2008.N.002
Yi-long Wu, Qing Zhou, Clinical trials and biomarker research on lung cancer in China Expert Opinion on Therapeutic Targets. ,vol. 16, pp. S45- S50 ,(2012) , 10.1517/14728222.2011.630663
Gail E Darling, Mark S Allen, Paul A Decker, Karla Ballman, Richard A Malthaner, Richard I Inculet, David R Jones, Robert J McKenna, Rodney J Landreneau, Valerie W Rusch, Joe B Putnam Jr, None, Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non–small cell carcinoma: Results of the American College of Surgery Oncology Group Z0030 Trial The Journal of Thoracic and Cardiovascular Surgery. ,vol. 141, pp. 662- 670 ,(2011) , 10.1016/J.JTCVS.2010.11.008
Glenwood D. Goss, Chris O'Callaghan, Ian Lorimer, Ming-Sound Tsao, Gregory A. Masters, James Jett, Martin J. Edelman, Rogerio Lilenbaum, Hak Choy, Fadlo Khuri, Katherine Pisters, David Gandara, Kemp Kernstine, Charles Butts, Jonathan Noble, Thomas A. Hensing, Kendrith Rowland, Joan Schiller, Keyue Ding, Frances A. Shepherd, Gefitinib Versus Placebo in Completely Resected Non–Small-Cell Lung Cancer: Results of the NCIC CTG BR19 Study Journal of Clinical Oncology. ,vol. 31, pp. 3320- 3326 ,(2013) , 10.1200/JCO.2013.51.1816