Chapter 8 Metabolism and intracellular processing of protein hormones

摘要: Publisher Summary This chapter discusses the various aspects of metabolism protein hormones. It describes how these regulatory molecules are synthesized and stored as precursor proteolytically processed to generate biologically active The mechanisms involved in secretion degradation also described. synthesis hormones is directed by one or more genes–with genes coding for amino-acid sequence other being responsible alterations peptide its final form. biosynthesis involves molecular forms larger than polypeptide secreted from cell. Proteolytic processing precursor-protein a widely used mechanism producing hormones, with exception few such growth hormone prolactin. cleavage prohormones begins only after folding prohormone-peptide chain completed endoplasmic reticulum (ER) peptides transferred concentrated Golgi area. Protein ribosomes form preprohormone, which inactive.