Cognitive‐behavioural treatment for amphetamine‐type stimulants (ATS) use disorders

摘要: Background Amphetamine-type stimulants (ATS) refer to a group of synthetic including amphetamine, methamphetamine, 3,4-methylenedioxy-methamphetamine (MDMA) and related substances. ATS are highly addictive prolonged use may result in series mental physical symptoms anxiety, confusion, insomnia, mood disturbances, cognitive impairments, paranoia, hallucinations delusion.Currently there is no widely accepted treatment for ATS-use disorder. However, cognitive-behavioural (CBT) the first-choice treatment. The effectiveness CBT other substance-use disorders (e.g. alcohol-, opioid- cocaine-use disorders) has been well documented as such this basic approach applied Objectives To investigate efficacy people with disorder reducing compared types psychotherapy, pharmacotherapy, 12-step facilitation, intervention or usual. Search methods We identified randomised controlled trials (RCT) quasi-RCTs comparing 12 step facilitation intervention. searched Cochrane Drugs Alcohol Group Specialised Register, Central Register Controlled Trials, MEDLINE via PubMed, Embase five databases up July 2018. In addition, we examined reference lists eligible studies systematic reviews. contacted experts field. Selection criteria Eligibility consisted RCTs versus interventions adult users (aged 18 years older) diagnosed by any explicit diagnostic system. Primary outcomes included abstinence rate indicators drug-using behaviours. Data collection analysis used standard methodological procedures expected Cochrane. Main results Only two met eligibility criteria. Both were at low risk selection bias reporting bias. one study, almost half participants dropped out study was high attrition single session brief web-based waiting-list control (total sample size across 129). Results mixed studies. For single-session measures drug produced significant results, percentage abstinent days 90 (odds ratio (OR) 0.22, 95% confidence interval (CI) 0.02 2.11) dependence (standardised mean difference (SMD) -0.59, CI -1.16 -0.02). Little could be placed from give small (25 per group) corresponding large CIs around observed effects. CBT, different outcomes. Neither reported adverse meta-analytic these not (SMD -0.28, -0.69 0.14). summary, overall quality evidence insufficient conclude that effective, ineffective, treating use. Authors' conclusions Currently, enough establish because paucity high-quality research area.