Role of cell-matrix contacts in cell migration and epithelial-mesenchymal transformation

摘要: Abstract Epithelial cells make contact with extracellular matrix via receptors on the basal surface that interact actin cortex. In 3D matrix, mesenchymal cell makes all around its circumference similar receptors. When moving, fibroblast is constantly constructing a new front end. We postulate in ‘fixed cortex’ theory of motility circumferential cortex firmly attached to and myosin-rich endoplasm slides past it into continually forming During epithelial-mesenchymal transformation, presumptive seems turn end mechanism as way emigrating from epithelium underlying which ‘fixed’ contacts. Master genes may exist regulate expression epithelial one hand, other.