Childbirth after adolescent and young adult cancer: a population-based study.

摘要: Annually, > 45,000 US women are diagnosed with cancer during adolescence and young adulthood (AYA). Since 2006, national guidelines have recommended fertility counseling for patients. We examined childbirth after AYA by calendar period, diagnosis, maternal characteristics. identified a cohort of an incident invasive diagnosis at ages 15–39 2000–2013 in North Carolina. Cancer records were linked statewide birth certificates through 2014. Hazard ratios (HR) 95% confidence intervals (CI) first post-diagnosis live calculated using Cox proportional hazards regression. Among 17,564 survivors, 1989 had ≥ 1 98,397 person-years. The 5- 10-year cumulative incidence was 10 15%, respectively. survivors younger lower stage disease, less often received chemotherapy than those without birth. 5-year 10.0% 2007–2012, compared to 9.4% 2000–2005 (HR = 1.01; 0.91, 1.12), corresponding periods before publication American Society Clinical Oncology 2006. Despite advances preservation options recognition as part high-quality care, the has remained stable over last 15 years. Our study uses data provide recent, population-based estimates how biological children diagnosis.