Di-n-Butyl Phthalate (DBP) Exposure Induces Oxidative Damage in Testes of Adult Rats
作者： Dangxia Zhou , Haixu Wang , Jing Zhang , Xiaoli Gao , Wenbao Zhao
DOI: 10.3109/19396368.2010.509902
关键词:
摘要: Di-n-butyl phthalate (DBP) is a ubiquitous environmental pollutant, extensively used as plasticizer in many products including plastics, cosmetics, and medical devices. Some studies have shown that DBP has potential testicular toxicity. However, the mechanism of action on male reproduction not clear. The present study was designed to further investigate reproductive toxicity . Oxidative stress assessed rat testes an underlying mechanism. Forty SD adult rats were randomly allotted four groups, administered each group by oral gavage at doses 0 (control), 100, 250, 500 mg/kg/d for 2 consecutive weeks. results indicated dose-dependent. Body weight significantly decreased exposure dose 500 mg/kg/d. Sperm count motility 250 same two inhibited activities superoxid...
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